Madness is any illness of the mind that limits rational thought. It can be brought about by any number of factors. The {{Lore Link|souls}} of madmen are the property of {{Lore Link|Sheogorath}}, the [[Lore:Daedric Princes|Daedric Prince]] of Madness.

Noxiphilic Sanguivoria is a strain of vampirism that was common during the {{Lore Link|Second Era}}. Unlike other vampiric diseases such as [[#Porphyric Hemophilia|Porphyric Hemophilia]] and [[#Sanguinare Vampiris|Sanguinare Vampiris]], vampires of the Noxiphilic Sanguivoria strain are not weakened by daylight, but are instead strengthened during the night. Vampires of this strain can undergo a complete blood transfusion ritual known as the Rite of the Scion to become Scions, a more powerful version of a vampire. The Rite of the Scion is also necessary for a [[Lore:Soul Shriven|Soul Shriven]] to become a vampire.